Minoxidil (U-10858) is a selective ATP dependent K+ channel (Kir6) activator. As a result membrane permeability increases the flow of K+ across the membrane, which turns off voltage gated calcium channels. This inhibition in action potential causes a relaxation in arteriolar smooth muscle. Alternate studies indicate that Minoxidil (U-10858) activates the β-catenin pathway in human dermal papilla cells which results in accumulation of β-catenin in the nucleus.
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Structure
Product Description
| Details | |
|---|---|
| Chemical Name | MINOXIDIL |
| IUPAC Name | 6-Piperidin-1-ylpyrimidine-2,4-diamine 3-oxide |
| CAS Number | 38304-91-5 |
| Molecular Formula | C9H15N5O |
| Synonyms | pdp;regain;lonolox;alostil;regaine;rogaine;U-10858;loniten;alopexil;prexidil |
| Application | A selective ATP dependent K+ (Kir6) channel activator. |